Publication: Considerations When Choosing High-Fat, High-Fructose, and High-Cholesterol Diets to Induce Experimental Nonalcoholic Fatty Liver Disease in Laboratory Animal Models

By Steven Yeung, M.S..

Sridhar Radhakrishnan, Steven F Yeung, Jia-Yu Ke, Maísa M Antunes, Michael A Pellizzon
Current Developments in Nutrition, Volume 5, Issue 12, December 2021

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is intricately linked to metabolic...

steve

Blog: Expression of SARS-CoV-2 entry proteins ACE2 and TMPRSS2 in rodents is affected by Obesity and Diabetes

By Dushyant Kshatriya, Ph.D. .

The COVID-19 pandemic has caused millions of deaths worldwide and caused significant impact on the global economy. The risk of severe coronavirus disease 2019 (COVID-19) is higher in people with diabetes and obesity. The exact mechanism by which obesity and diabetes contribute to the pathophysiology of COVID-19 is unknown and one of the key player is believed to be related to the renin-angiotensin system (RAS).

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dushyant

Webinar: Consider The Diet Carefully For Your Gut Microbiome Research

By Mark D'Antonio.

Join Dr. Mike Pellizzon for his presentation at the Swiss Laboratory Animal meeting this Friday. Diet is an important consideration when designing your rodent studies for gut microbiome research; in particular, fiber is a key factor that can drive changes.

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mark

Blog: Comprehensive characterization of an off-the-shelf AMLN mouse model and considerations for experimental design in NASH pre-clinical research

By Steven Yeung, M.S..

Rodent Diet With 40 kcal% Fat (Mostly Palm Oil), 20 kcal% Fructose and 2% Cholesterol(D09100310) has been tested by the Danish contract research organization, Gubra, and is also referred to as the Gubra-Amlyin NASH (GAN) diet in the literature.

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steve

Webinar: Is It Time to Revise the AIN-93 Rodent Diet Formulas?

By Michael A. Pellizzon, Ph.D..

This important question will be addressed at a special session during NUTRITION 2021 LIVE ONLINE, June 9, 2021 from 2:00 – 3:30 PM EDT. Michael A. Pellizzon, PhD from Research Diets, Inc. is presenting.

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mike

Blog: A Translational Mouse Model for NASH

By Sridhar Radhakrishnan, Ph.D..

An interesting publication using NASH diets ...

A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

Anita M. van den Hoek 1,*, Lars Verschuren 2, Nicole Worms 1, Anita van...

sri

Publication: Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models

By Sridhar Radhakrishnan, Ph.D..

Sridhar Radhakrishnan, Jia-Yu Ke, Michael A Pellizzon
Current Developments in Nutrition, Volume 4, Issue 6, June 2020

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is a complex spectrum of disorders ranging from simple benign steatosis to more...

sri

Publication: Choice of Laboratory Rodent Diet May Confound Data Interpretation and Reproducibility

By Michael A. Pellizzon, Ph.D..

Michael A Pellizzon and Matthew R Ricci
Research Diets, Inc, New Brunswick, NJ, USA

ABSTRACT
The reproducibility of experimental data is challenged by many factors in both clinical and preclinical research. In preclinical studies, several factors...

mike

The biggest study that's been done in mouse nutrition in 50 years by John Speakman, PhD

By Mark D'Antonio.

In a landmark paper published in Cell Metabolism in September of 2018,  John Speakman, (with joint appointments at University of Aberdeen and the Chinese Academy of Sciences) et al., studied the effects of 29 different diets that varied in...

mark

The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor

By Mark D'Antonio.

Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat grain-based (GB) diet containing...

mark