Despite evidence suggesting that natural products protect against obesity and metabolic syndrome in cell culture and animal models, results oftentimes do not translate in human clinical trials. One possible explanation for this finding is the continual use of highly inbred mouse strains (notably C57BL6/J) in obesity research. Obesity is multi-factorial disease with diverse etiologies in humans, and is not necessarily directly replicated by the C57BL6/J model. Therefore, the goal of this study was to examine the diet-induced onset of obesity and subsequent amelioration by quercetin, a dietary flavonoid, in the context of a genetically diverse population of mice. A subset of the Collaborative Cross founder strains (males and females) were placed on different dietary treatments and diverse phenotypic responses were observed. This highlights need to move away from traditional inbred mouse models in obesity research to enhance translatability to the human population.
Diet-Induced Obesity in Genetically Diverse Collaborative Cross Mouse Founder Strains Reveals Diverse Phenotype Response and Amelioration by Quercetin Treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ and WSB/EiJ Mice