steve By Steven Yeung, M.S..

Registration is open for the webinar: “Dietary Considerations to Optimize NASH in Rodent Models” that will be presented by Dr. Sridhar Radhakrishnan. This webinar is hosted by Taconic Biosciences and is part of their Nonalcoholic Steatohepatitis (NASH) Symposium entitled: “Advancing NASH Research with Mice: Best Practices and Applications of Westernized Diets.”

Date: Thursday, August 25, 2022, 11 AM ET

Register here:

Key takeaways from this webinar include:

1. Different models of Nonalcoholic fatty liver disease (NAFLD) in rodents with details on nutrient modifications in animal diets and timeframes for phenotype development.
2. Advantages and disadvantages of different models of rodent NASH/fibrosis.
3. Tips on NASH model selection including identifying the right rodent model/strain, and choosing appropriate experimental and control diets.

NAFLD is a complex spectrum of disorders ranging from simple benign steatosis to more aggressive forms of NASH and fibrosis. Purified diets formulated with specific nutritional components can drive the entire spectrum of NAFLD in rodent models. Although they may not perfectly replicate the clinical and histological features of human NAFLD, they provide a model to gain further understanding of disease progression in humans. Because of the growing demand for diets for NAFLD research, using our unique understanding of how manipulation of dietary components can alter disease development, the webinar will outline different dietary approaches for NAFLD development in rodent models, and will discuss the timeframes required for disease development and whether human-like NAFLD metabolic disease comorbidities also develop.

Sri’s background is in Pharmaceuticals and Fine Chemicals and he received his PhD in Food Science and Human Nutrition from Colorado State University. Before joining Research Diets, Inc., Sri was a Post-doctoral Scholar in the Department of Food Science, Pennsylvania State University. He has worked with both in vitro and in vivo (mouse and pig) models to screen, evaluate toxicity, study efficacy, and potency of anti-inflammatory and anti-cancer phytochemicals. His background gives him a strong and a unique perspective to assist researchers with their laboratory animal diet formulation needs. He has thoroughly enjoyed helping and collaborating with researchers on different diet induced phenotypes in the last seven years at Research Diets, Inc.