The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor
Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat grain-based (GB) diet containing...
Are you familiar with the difference between a grain based chow and a purified ingredient diet? RDI's Senior Scientist Dr.Michael Pellizzon talks about differences between these two types of diets and how they can influence the intestinal health...
If your study involves in vivo imaging using fluorescence technologies, it's very important that the 'background' or 'noise' signal be as low as possible. Unfortunately, many commonly used grain-based chow diets contain chlorophyll, which fluoresces at 680 nm and can therefore interfere with the detection of fluorophores. The result is that the GI tract of the animal will fluoresce and your signal of interest may be hard or impossible to quantify.Read more
Researchers should pay closer attention to the diets they use to study obesity in mice, experts advise. One of those experts is our own Matthew Ricci, Ph. D.- VP/Science Director. The article appears online in the Scientist.
How important is a good control diet? Can't you just use chow as a control? (Short answer: No!)
Proper control diets are critical to valid data interpretation.
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Understandably, many customers are concerned about whether our production process involves any extreme temperatures or pressure. This is especially true when we are incorporating a sensitive compound. The answer is, no, diets are not exposed to...
Low Doses of Arsenic on Immunity and Development: Requirement of Purified Open Source Diets in Toxicological Research
In 2008, Kozul-Horvath and Hamilton found that mice fed a grain-based chow (Purina 5001) had no changes in gene expression when exposed to arsenic while they were dramatic when fed purified diet AIN-76A (Click here for pdf). They found out that...
- The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor
- Are you choosing the right diets to make your mice fat?
- Intestinal Health: Are you choosing the right type of diet for your lab animals?
- Does Diet matter when performing animal imaging studies?
- Inside a Lab Mouse's High-Fat Diet
- Are control diets important?
- Diets are not exposed to extreme temperatures during production
- When to Change Diet
- Low Doses of Arsenic on Immunity and Development: Requirement of Purified Open Source Diets in Toxicological Research