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Metabolic Syndrome

The Metabolic syndrome (MS) is a term used to describe the simultaneous occurrence of insulin resistance, abnormal blood lipid levels (hypertriglyceridemia and reduced high density lipoprotein cholesterol), and hypertension (high blood pressure). People with the MS are at increased risk for type 2 diabetes, cardiovascular disease, cancer, and nonalcoholic fatty liver disease. While certain people may be more susceptible to the MS than others, one key factor that may drive the MS in humans is diet. Like humans, certain rodent models are more sensitive than others to dietary changes. Examples of how various diets can affect the MS in rodent models are shown in the table below. To read more, see our Product Literature.

Product Literature

Type of Diet Commonly Used Strains Phenotype Comments
Purified ingredient diet, 45-60 kcal% fat with various fat sources C57BL/6 mice Obesity/hyperglycemia BW differences between high fat and low fat diets groups appear as early as 1 week on diet. Hyperglycemia occurs around 4 weeks.
Purified ingredient diet, 10 or 58 kcal% fat with various fat and CHO sources A/J mice Obesity resistance Do not become obese despite caloric intake similar to C57BL/6 mice.
Purified ingredient diet, 32 kcal% fat SD rat Hypertension Hypertension and obesity developed after 10 weeks on high fat diet.
Purified ingredient diet, 8% NaCl Dahl SS rat Hypertension Hypertension developed after 2-4 weeks on diet.
Purified ingredient diet, 60 -70 kcal% sucrose SD rat, Wistar rat IR/hypertriglyceridemia Both IR and hypertriglyceridemia after 2 weeks on diet.
Purified ingredient diet, 60 -70 kcal% fructose Golden Syrian Hamster IR/hypertriglyceridemia Both IR and hypertriglyceridemia after 2 weeks on diet.
Purified ingredient diet, high saturated fat, 1% cholesterol, 0.25% cholic acid C57BL/6 mice Atherosclerosis/ Hypercholesterolemia Hypercholesterolemia and mild atherosclerosis after 14-18 weeks on diet.
Purified ingredient diet, 0.1 - 1.25% cholesterol LDL receptor KO, apolipoprotein E KO Atherosclerosis/ Hypercholesterolemia Hypercholesterolemia and atherosclerosis after 12 weeks on diet.

See full table with references in product literature.

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Dima 1010

Dima Paone, MB BCh.

International Marketing Specialist and Scientist
Juliet 1087

Juliet Gentile, Ph.D.

Scientist- BioDAQ/ Diet
Holly 0947

Jia-Yu Ke, Ph.D.

Project Manager and Scientist