Genetic and environmental factors play a role in the development of obesity, and diet is one of the main environmental factors that contribute to obesity and its related metabolic diseases. Human studies have shown that increased fat intake is associated with body weight gain which can lead to obesity and other related metabolic diseases. As such, rodent animal models are useful tools to determine the mechanistic aspects of obesity and to develop therapeutic approaches as they will readily gain weight when fed high-fat diets. To read more, see our Product Literature.
Important factors to consider when designing a diet-induced obesity study using animal models are:
*For those requiring a matched control diet, be sure to use a purified ingredient matched diet rather than a grain-based diet.