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DIO Series Diets

Diet-Induced Obesity (DIO)

Research Diets, Inc. is well known as the gold standard in high-fat diets for diet-induced obesity research worldwide. Below are the most widely published diets for these studies. All high-fat diets are not the same. We have made hundreds of modifications to these formulas to meet individual researcher needs. Please consult with one of our scientists before choosing a high-fat diet for your next study.

Diet Formula Description Google Scholar
D12492 DIO (VHFD) 60 kcal% fat References
D12451 DIO (HFD) 45 kcal% fat References
D12450B Control (LFD) 10 kcal% fat 35% Sucrose References
D12450H Control (LFD) 10 kcal% fat D12451 Match 17% Sucrose References
D12450J Control (LFD) 10 kcal% fat D12492 Match 7% Sucrose References
D12450K Control (LFD) 10 kcal% fat No Sucrose References

The D12492 Story 

On April 22, 1999 the first box of pelleted D12492 was shipped. In 1999 Research Diets shipped 150 kg of D12492, and today ships over 10,000 kg of D12492 monthly. Today, there are more DIO rodent models made using our diets than any other diets in the world. More than 1,500,000 kilos of D12492 has shipped to more than 3,000 researchers, working at more than 800 separate institutions in more than 60 countries .

D12492 began as a custom diet and because of its continued use, is now a gold standard for (DIO) Diet-Induced Obesity research. As its popularity grew, D12492 became an “In-Stock Diet”. There are many different customized diets that have been based on D12492. For more, please contact our science group.

What It Means

Since the first box shipped, these diets have become the standard for research in the field of obesity, diabetes, and metabolic syndrome. Top worldwide breeders Charles River, Taconic and JAX, feed D12492 to produce DIO mice for the research community. A recent Google Scholar search revealed over 3,600 publications in which these diets were utilized. By using these standards, investigators are privy to a wide range of reference data from an expanding research publication base.

D12492 is only 1 of the more than 20,000 diets we’ve formulated and produced and there’s more every day.

A Word of Caution 

Don’t be misled by diet manufacturers who claim to offer the same OpenSource diet formulas as Research Diets, Inc. Though it is true that all our formulas are open, there may be differences in the sources of ingredients or the vitamin and mineral mixes used to produce the diet. There is only one sure way to repeat research based on the "Original" OpenSource Diet formula—go to the source of that formula. There is only one place to get OpenSource Diets and that’s at Research Diets, Inc.

Product Literature

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Steven Yeung, M.S.

Project Manager and Scientist
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Dima Paone, MB BCh.

Global Logistics Director and Scientist
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Michael A. Pellizzon, Ph.D.

Senior Scientist