A number of custom OpenSource diet formulations have been widely published and have become the standards for many diet-induced disease models. These custom diets are kept in-stock in pelleted form and ready for shipment. Our in-stock custom diets provide a clean, open formula background in which to make modifications. See our custom diets page for more information on other custom formulations.
The following is a list of our in-stock purified diets:
All our in-stock diets can be irradiated. To order irradiated diets add the letter "i" to the end of the diet number. For example D12492i.
Diet-Induced Obesity (DIO)
Research Diets, Inc. is well known as the gold standard in high-fat diets for diet-induced obesity research worldwide. Below are the most widely published diets for these studies. All high-fat diets are not the same. We have made hundreds of modifications to these formulas to meet individual researcher needs. Please consult with one of our scientists before choosing a high-fat diet for your next study. Read more.
The following is a list of our in-stock DIO Series Diets:
Methionine and Choline Deficient (MCD) Diets Among the different approaches for diet-induced NAFLD in rodents, MCD diets produce the most severe NASH phenotype in the shortest timeframe. MCD diets are formulated with the replacement of whole protein (such as casein) in purified diets with crystalline amino acids and the removal of both methionine and choline. Read more
Choline Deficient (CD) Diets Typically, CD diets used in fatty liver disease studies tend to contain higher levels of fat (45-60 kcal%) and these diets can induce steatosis, inflammation and fibrosis without the reduction in body weight typically found when feeding MCD diets, making CD diets more appealing to some researchers. Read more
High-Fat, High-Fructose, High-Cholesterol Diets Studies in C57BL/6 mice fed a HFD or high-fat, high-fructose (HFHFr) diet (58 Kcal% fat) with high-fructose corn syrup in water for 16 weeks showed that fructose consumption was necessary for the progression from liver fat deposition to fibrogenesis. Read more
The following is a list of our in-stock NASH Diets:
Report, Repeat and Revise
When choosing a control diet, one should ask three questions: Can I report it (can I tell others exactly what my animals were fed)? Can I repeat it (is there diet variability and will I be able to get the same results next year)? Can I revise it (as my hypotheses change, can I easily change the dietary components while keeping it otherwise matched to previous diets)? The answer should be “yes” to all three. Additionally the control diet formula should be matched to that of the experimental diet.
Pellizzon and Ricci , The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor. Nutrition & Metabolism (2018) 15:3. Download publication
The following is a list of our in-stock Control Diets: